| http://purl.uniprot.org/citations/14993927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14993927 | http://www.w3.org/2000/01/rdf-schema#comment | "We show that mice expressing retinoid X receptor beta (RXRbeta) impaired in its transcriptional activation function AF-2 (Rxrb(af20) mutation) do not display the spermatid release defects observed in RXRbeta-null mutants, indicating that the role of RXRbeta in spermatid release is ligand-independent. In contrast, like RXRbeta-null mutants, Rxrb(af20) mice accumulate cholesteryl esters in Sertoli cells (SCs) due to reduced ABCA1 transporter-mediated cholesterol efflux. We provide genetic and molecular evidence that cholesterol homeostasis in SCs does not require PPARalpha and beta, but depends upon the TIF2 coactivator and RXRbeta/LXRbeta heterodimers, in which RXRbeta AF-2 is transcriptionally active. Our results also indicate that RXRbeta may be activated by a ligand distinct from 9-cis retinoic acid."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400094"xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/author | "Auwerx J."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/author | "Ghyselinck N.B."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/author | "Mark M."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/author | "Mascrez B."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/author | "Annicotte J.S."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/pages | "285-290"xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/title | "Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells."xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/14993927 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14993927 |
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