| http://purl.uniprot.org/citations/14996832 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14996832 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14996832 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies using the nematode Caenorhabditis elegans as a model system to investigate the aging process have implicated the insulin/insulin-like growth factor-I signaling pathway in the regulation of organismal longevity through its action on a subset of target genes. These targets can be classified into genes that shorten or extend life-span upon their induction. Genes that shorten life-span include a variety of stress response genes, among them genes encoding catalases; however, no evidence directly implicates catalases in the aging process of nematodes or other organisms. Using genetic mutants, we show that lack of peroxisomal catalase CTL-2 causes a progeric phenotype in C. elegans. Lack of peroxisomal catalase also affects the developmental program of C. elegans, since Deltactl-2 mutants exhibit decreased egg laying capacity. In contrast, lack of cytosolic catalase CTL-1 has no effect on either nematode aging or egg laying capacity. The Deltactl-2 mutation also shortens the maximum life-span of the long lived Deltaclk-1 mutant and accelerates the onset of its egg laying period. The more rapid aging of Deltactl-2 worms is apparently not due to increased carbonylation of the major C. elegans proteins, although altered peroxisome morphology in the Deltactl-2 mutant suggests that changes in peroxisomal function, including increased production of reactive oxygen species, underlie the progeric phenotype of the Deltactl-2 mutant. Our findings support an important role for peroxisomal catalase in both the development and aging of C. elegans and suggest the utility of the Deltactl-2 mutant as a convenient model for the study of aging and the human diseases acatalasemia and hypocatalasemia."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m400207200"xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m400207200"xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/author | "Rachubinski R.A."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/author | "Rachubinski R.A."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/author | "Petriv O.I."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/author | "Petriv O.I."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/pages | "19996-20001"xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/pages | "19996-20001"xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/title | "Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/title | "Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14996832 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14996832 |
| http://purl.uniprot.org/citations/14996832 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14996832 |
| http://purl.uniprot.org/citations/14996832 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14996832 |
| http://purl.uniprot.org/citations/14996832 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14996832 |
| http://purl.uniprot.org/uniprot/O61235 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14996832 |
| http://purl.uniprot.org/uniprot/Q27487 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14996832 |