| http://purl.uniprot.org/citations/15000751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15000751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15000751 | http://www.w3.org/2000/01/rdf-schema#comment | "Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a unique scavenger receptor that plays important roles in atherogenesis and has been thought to function as a monomer. Using coimmunoprecipitation studies, we demonstrate that human LOX-1 (hLOX-1) forms constitutive homo-interactions in vivo. Western blot analysis of cell lysates under nonreducing or reducing conditions revealed one clear immunoreactive species corresponding to the size of a putative receptor dimer or a monomer, respectively, consistent with the presence of disulfide-linked hLOX-1 complexes. Site-directed mutagenesis studies indicated that cysteine 140 has a key role in the formation of these disulfide-linked hLOX-1 dimers. Eliminating this intermolecular disulfide bond markedly impairs the recognition of Escherichia coli by hLOX-1. Furthermore, these dimers can act as a "structural unit" to form noncovalently associated oligomers, as demonstrated by a membrane-impermeant crosslinker, which resulted in immunoreactive species corresponding to the sizes of putative tetramers and hexamers. These results provide the first evidence for the existence of hLOX-1 dimers/oligomers."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.org/dc/terms/identifier | "doi:10.1089/104454904322759920"xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.org/dc/terms/identifier | "doi:10.1089/104454904322759920"xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Matsunaga S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Matsunaga S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Xie Q."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Xie Q."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Sakakibara Y."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Sakakibara Y."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Machida S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Machida S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Tokuyasu K."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Tokuyasu K."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Niimi S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/author | "Niimi S."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/name | "DNA Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/name | "DNA Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/pages | "111-117"xsd:string |
| http://purl.uniprot.org/citations/15000751 | http://purl.uniprot.org/core/pages | "111-117"xsd:string |