| http://purl.uniprot.org/citations/15001579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15001579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15001579 | http://www.w3.org/2000/01/rdf-schema#comment | "Although plasminogen activator inhibitor-1 (PAI-1) is known to stimulate cell migration, little is known about underlying mechanisms. We show that both active and inactive (e.g. cleaved) PAI-1 can activate the Jak/Stat signaling system and stimulate cell migration in chemotaxis, haptotaxis, chemokinesis, and wound healing assays. Moreover, antibodies to the LDL receptor-related protein (LRP) and an LRP antagonist (RAP) blocked these motogenic effects of PAI-1, while a PAI-1 mutant that did not bind to LRP failed to activate the Jak/Stat signaling pathway or to stimulate cell migration. PAI-1 had no chemotactic effect on LRP-deficient cells. These results indicate that LRP is a signaling molecule, that it mediates the migration-promoting activity of PAI-1, and that this activity does not require intact, biologically active PAI-1. Activation of this LRP-dependent signaling pathway by PAI-1 may begin to explain how the inhibitor stimulates cell migration in a variety of normal and pathological processes."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313004200"xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313004200"xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Aertgeerts K."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Aertgeerts K."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Kamikubo Y."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Kamikubo Y."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Czekay R.P."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Czekay R.P."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Degryse B."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Degryse B."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Loskutoff D.J."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Loskutoff D.J."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Neels J.G."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/author | "Neels J.G."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/pages | "22595-22604"xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/pages | "22595-22604"xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/title | "The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1."xsd:string |
| http://purl.uniprot.org/citations/15001579 | http://purl.uniprot.org/core/title | "The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1."xsd:string |