| http://purl.uniprot.org/citations/15003812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15003812 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the correlation between clinical features and HLA DR/DQ genetic variability in myasthenia gravis (MG), we evaluated HLA DR/DQ allele frequencies in 87 Japanese patients with childhood-onset disease. HLA genotypes DRB1*1302/DQA1*0102/DQB1*0604 and DRB1*0901/DQA1*0301/DQB1*0303 were significantly higher in patients than in healthy controls (P(c) < 0.0001, RR = 5.5; P(c) < 0.0001, RR = 8.5, for two genotypes, respectively). Patients who had a significantly higher likelihood of the HLA types DRB1*1302/DQA1*0102/DQB1*0604 or DRB1*0901/DQA1*0301/DQB1*0303 belonged to the latent general type (LG) of MG; this is clinically ocular type, but shows myasthenic electromyographic findings in extremity muscles. The LG type of MG was observed in 78% of patients exhibiting the clinically ocular type; this group comprised approximately 75% of patients with childhood-onset MG. These date suggest that LG type of MG may present a particular subset of childhood-onset MG, which is associated with the specific HLA subtypes DRB1*1302/DQA1*0102/DQB1*0604 and DRB1*0901/DQA1*0301/DQB1*0303."xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.clim.2003.10.004"xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/author | "Nomura Y."xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/author | "Shinomiya N."xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/author | "Segawa M."xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/pages | "154-158"xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/title | "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan."xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/15003812 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15003812 |
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