| http://purl.uniprot.org/citations/15004009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15004009 | http://www.w3.org/2000/01/rdf-schema#comment | "In cycling cells, transcription of ribosomal RNA genes by RNA polymerase I (Pol I) is tightly coordinated with cell growth. Here, we show that the mammalian target of rapamycin (mTOR) regulates Pol I transcription by modulating the activity of TIF-IA, a regulatory factor that senses nutrient and growth-factor availability. Inhibition of mTOR signaling by rapamycin inactivates TIF-IA and impairs transcription-initiation complex formation. Moreover, rapamycin treatment leads to translocation of TIF-IA into the cytoplasm. Rapamycin-mediated inactivation of TIF-IA is caused by hypophosphorylation of Se 44 (S44) and hyperphosphorylation of Se 199 (S199). Phosphorylation at these sites affects TIF-IA activity in opposite ways, for example, phosphorylation of S44 activates and S199 inactivates TIF-IA. The results identify a new target formTOR-signaling pathways and elucidate the molecular mechanism underlying mTOR-dependent regulation of RNA synthesis."xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.285504"xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/author | "Mayer C."xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/author | "Yuan X."xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/author | "Grummt I."xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/pages | "423-434"xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/title | "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability."xsd:string |
| http://purl.uniprot.org/citations/15004009 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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