| http://purl.uniprot.org/citations/15004026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15004026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15004026 | http://www.w3.org/2000/01/rdf-schema#comment | "The viral mitochondria-localized inhibitor of apoptosis (vMIA), encoded by the UL37 gene of human cytomegalovirus, inhibits apoptosis-associated mitochondrial membrane permeabilization by a mechanism different from that of Bcl-2. Here we show that vMIA induces several changes in Bax that resemble those found in apoptotic cells yet take place in unstimulated, non-apoptotic vMIA-expressing cells. These changes include the constitutive localization of Bax at mitochondria, where it associates tightly with the mitochondrial membrane, forming high molecular weight aggregates that contain vMIA. vMIA recruits Bax to mitochondria but delays relocation of caspase-8-activated truncated Bid-green fluorescent protein (GFP) (t-Bid-GFP) to mitochondria. The ability of vMIA and its deletion mutants to associate with Bax and to induce relocation of Bax to mitochondria correlates with their anti-apoptotic activity and with their ability to suppress mitochondrial membrane permeabilization. Taken together, our data indicate that vMIA blocks apoptosis via its interaction with Bax. vMIA neutralizes Bax by recruiting it to mitochondria and "freezing" its pro-apoptotic activity. These data unravel a novel strategy of subverting an intrinsic pathway of apoptotic signaling."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m308408200"xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m308408200"xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Larochette N."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Larochette N."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Zamzami N."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Zamzami N."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Martinou J.C."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Martinou J.C."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Poncet D."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Poncet D."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Bartle L.M."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Bartle L.M."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Boutolleau D."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Boutolleau D."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Boya P."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Boya P."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Cartron P.F."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Cartron P.F."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Goldmacher V.S."xsd:string |
| http://purl.uniprot.org/citations/15004026 | http://purl.uniprot.org/core/author | "Goldmacher V.S."xsd:string |