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http://purl.uniprot.org/citations/15005011http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15005011http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The N-acetyltransferase polymorphism is involved in the metabolism of many xenobiotics, as well as in susceptibility to some diseases such as rheumatoid arthritis (RA). The aim of this study was to investigate the influence of NAT 2 polymorphism on disease activity in RA patients.

Methods

70 with RA were enrolled in the study. As a measure of disease activity, the number of swollen and tender joints, the duration of morning stiffness, ESR and CRP as well as disease activity based on a global physician's assessment were evaluated. The NAT2 polymorphism was determined by a polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP).

Results

The mean number of swollen and tender joints, as well as the ESR and CRP values, did not differ significantly with the acetylation genotype. Erosive RA was diagnosed in 74.5% of the slow and 40% of the fast acetylators. The risk for the development of erosive RA was 4.39 time greater in slow acetylators than in fast acetylators.

Conclusion

NAT2 polymorphism may be a genetic risk factor for joint destruction."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/author"Pawlik A."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/author"Gawronska-Szklarz B."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/author"Brzosko I."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/author"Brzosko M."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/author"Dabrowska-Zamojcin E."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/author"Ostanek L."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/name"Clin Exp Rheumatol"xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/pages"99-102"xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/title"The influence of N-acetyltransferase 2 polymorphism on rheumatoid arthritis activity."xsd:string
http://purl.uniprot.org/citations/15005011http://purl.uniprot.org/core/volume"22"xsd:string
http://purl.uniprot.org/citations/15005011http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15005011
http://purl.uniprot.org/citations/15005011http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15005011
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http://purl.uniprot.org/uniprot/#_A4Z6U6-mappedCitation-15005011http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15005011
http://purl.uniprot.org/uniprot/#_A4Z6U7-mappedCitation-15005011http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15005011
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