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| http://purl.uniprot.org/citations/15006385 | http://www.w3.org/2000/01/rdf-schema#comment | "Screening of our compound collection using Staphylococcus aureus Ni-Peptide deformylase (PDF) afforded a very potent PDF inhibitor with an IC(50) in the low nanomolar range but with poor antibacterial activity (MIC). Three-dimensional structural information obtained from Pseudomonas aeruginosa Ni-PDF complexed with the inhibitor suggested the synthesis of a variety of analogues that would maintain high binding affinity while attempting to improve antibacterial activity. Many of the compounds synthesized proved to be excellent PDF-Ni inhibitors and some showed increased antibacterial activity in selected strains."xsd:string |
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| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Biorac T."xsd:string |
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| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Kreusch A."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Shin T."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Bursulaya B."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Doughty J."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Warner I."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Ryder N.S."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Goldberg R."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Molteni V."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/author | "Nabakka J."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/name | "Bioorg Med Chem Lett"xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/pages | "1477-1481"xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/title | "Identification of novel potent bicyclic peptide deformylase inhibitors."xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15006385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15006385 |
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