| http://purl.uniprot.org/citations/15012138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15012138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15012138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/15012138 | http://www.w3.org/2000/01/rdf-schema#comment | "Thiazole synthase (ThiG) catalyzes an Amadori-type rearrangement of 1-deoxy-d-xylulose-5-phosphate (DXP) via an imine intermediate. In support of this, we have demonstrated enzyme-catalyzed exchange of the C2 carbonyl of DXP. Borohydride reduction of the enzyme DXP imine followed by top-down mass spectrometric analysis localized the imine to lysine 96. On the basis of these observations, a new mechanism for the biosynthesis of the thiazole phosphate moiety of thiamin pyrophosphate in Bacillus subtilis is proposed. This mechanism involves the generation of a ketone at C3 of DXP by an Amadori-type rearrangement of the imine followed by nucleophillic addition of the sulfur carrier protein (ThiS-thiocarboxylate) to this carbonyl group."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.org/dc/terms/identifier | "doi:10.1021/ja039616p"xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.org/dc/terms/identifier | "doi:10.1021/ja039616p"xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Begley T.P."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Begley T.P."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Dorrestein P.C."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Dorrestein P.C."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "McLafferty F.W."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "McLafferty F.W."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Zhai H."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Zhai H."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Taylor S.V."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/author | "Taylor S.V."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/name | "J. Am. Chem. Soc."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/name | "J. Am. Chem. Soc."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/pages | "3091-3096"xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/pages | "3091-3096"xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/title | "The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/title | "The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase."xsd:string |
| http://purl.uniprot.org/citations/15012138 | http://purl.uniprot.org/core/volume | "126"xsd:string |