| http://purl.uniprot.org/citations/15012602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15012602 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of murine oncostatin M (mOSM) are specifically mediated by the heterodimeric oncostatin M receptor (OSMR)/gp130 receptor complex. In the current study we demonstrate that murine adrenocortical Y-1 tumor cells express the OSMR/gp130 complex. Incubation of Y-1 cells with 1 and 10 ng/ml mOSM induces cell death due to specific induction of apoptosis. Western blot analysis of Y-1 cells incubated with mOSM for 24 h revealed caspase-3 cleavage and poly(ADP-ribase) polymerase (PARP) cleavage. In a proliferation assay system, incubation of Y-1 cells with 0.01, 0.1, 1 and 10 ng/ml mOSM for 24 h resulted in a decrease in cell numbers to 99+/-2%, 84+/-9%, 50+/-7% and 43+/-5% respectively of untreated control (defined as 100%). Pretreatment of Y-1 cells with the Jak2 inhibitor AG490 (100 microM) rescued Y-1 cells from OSM-induced (10 ng/ml) cell death. Similarly, pretreatment of Y-1 cells with the general caspase inhibitor Z-VAD-FMK (42 microM) rescued Y-1 cells from OSM-induced (10 ng/ml) cell death. In summary, we show that adrenocortical Y-1 tumor cells express the OSMR/gp130 complex and that mOSM induces the Jak-STAT signaling cascade in these cells. Murine OSM in a dose-dependent manner induces apoptosis in adrenocortical Y-1 tumor cells. Apoptosis was demonstrated by caspase-3 cleavage and PARP cleavage. Rescue of Y-1 cells from mOSM-induced apoptosis by the Jak2 inhibitor, AG490, and the general caspase inhibitor, Z-VAD-FMK, demonstrates Jak activation and subsequent caspase activation to be essential for mOSM-induced apoptosis in adrenocortical Y-1 tumor cells. The putative role of OSM as an immunotherapeutic agent in human adrenocortical cancer remains to be elucidated."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.org/dc/terms/identifier | "doi:10.1677/joe.0.1800479"xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Weber M.M."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Auernhammer C.J."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Engelhardt D."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Cengic N."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Kopp F.B."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Spoettl G."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Hengge S."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Vlotides G."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/author | "Dorn F."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/name | "J Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/pages | "479-486"xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/title | "The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells."xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/15012602 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15012602 |
| http://purl.uniprot.org/citations/15012602 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15012602 |
| http://purl.uniprot.org/uniprot/Q62120#attribution-E4835D195763CD9DCD9CED0B84BBEEC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15012602 |
| http://purl.uniprot.org/uniprot/P09056#attribution-065017B373F55BE9B15F059426F20939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15012602 |
| http://purl.uniprot.org/uniprot/P53347#attribution-065017B373F55BE9B15F059426F20939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15012602 |
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| http://purl.uniprot.org/uniprot/#_B9EHD2-mappedCitation-15012602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15012602 |