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http://purl.uniprot.org/citations/15013623 | http://www.w3.org/2000/01/rdf-schema#comment | "During early postnatal development, a switch occurs between eEF1A-1/EF-1alpha and eEF1A-2/S1, homologous peptide elongation factors, in brain, heart, and skeletal muscle; eEF1A-2/S1 becomes the major form expressed in maturity. By immunofluorescent labeling, we detected both homologues in the developing brains of wild-type and wasted mutant mice, carrying a deletion in the eEF1A-2/S1 gene; we found that brain expression of eEF1A-2/S1 protein is restricted to mature, terminally differentiated neurons, and coincides with the disappearance of eEF1A-1/EF-1alpha 20 days after birth. Furthermore, no elongation factor 1A is present in wasted mutant mice neurons following the developmental switch, indicating that the genetic regulation silencing eEF1A-1/EF-1alpha is still functional."xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devbrainres.2003.10.011"xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/author | "Pan J."xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/author | "Wang E."xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/author | "Ruest L.B."xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/name | "Brain Res Dev Brain Res"xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/pages | "1-8"xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/title | "Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development."xsd:string |
http://purl.uniprot.org/citations/15013623 | http://purl.uniprot.org/core/volume | "149"xsd:string |
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