| http://purl.uniprot.org/citations/15013978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15013978 | http://www.w3.org/2000/01/rdf-schema#comment | "Insofar as genetic susceptibility to type 1 diabetes is associated with HLA class II genes, with certain allelic combinations conferring disease susceptibility or resistance, this study assessed the distributions of HLA-DR and -DQ among 107 unrelated patients with type 1 diabetes and 88 healthy controls from Bahrain, all of Arab origin. The HLA-DRB and -DQB genotypes were determined by PCR-sequence-specific priming. The following alleles showed the strongest association with type 1 diabetes among patients versus controls according to their frequencies: DRB1*030101 (0.430 versus 0.097; P < 0.001), DRB1*040101 (0.243 versus 0.034; P < 0.001), DQB1*0201 (0.467 versus 0.193; P < 0.001), and DQB1*0302 (0.229 versus 0.091; P < 0.001). When the frequencies of alleles in controls were compared to those in patients, negative associations were seen for DRB1*100101 (0.085 versus 0.014; P < 0.001), DRB1*110101 (0.210 versus 0.060; P < 0.001), DQB1*030101 (0.170 versus 0.075; P = 0.006), and DQB1*050101 (0.335 versus 0.121; P < 0.001). In addition, the DRB1*030101-DQB1*0201 (70.1 versus 22.7%; P < 0.001) and DRB1*030101-DQB1*0302 (21.5 versus 0.0%; P < 0.001) genotypes were more prevalent among patients, thereby conferring disease susceptibility, whereas the DRB1*100101-DQB1*050101 (20.5 versus 2.8%; P < 0.001), DRB1*110101-DQB1*030101 (28.4 versus 8.4%; P < 0.001), and DRB1*110101-DQB1*050101 (30.7 versus 0.9%; P < 0.001) genotypes were more prevalent among controls, thus assigning a protective role. These results confirm the association of specific HLA-DR and -DQ alleles and haplotypes with type 1 diabetes and may underline several characteristics that distinguish Bahraini patients from other Caucasians patients."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.org/dc/terms/identifier | "doi:10.1128/cdli.11.2.292-296.2004"xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "Kamal M."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "Almawi W.Y."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "Tamim H."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "Abbassi A.J."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "Al-Harbi E.M."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "Kooheji M."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "Motala A.A."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "al-Jenaidi F."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "al-Mahroos S."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/author | "al-Nasir F."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/name | "Clin Diagn Lab Immunol"xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/pages | "292-296"xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/title | "Specific HLA-DRB and -DQB alleles and haplotypes confer disease susceptibility or resistance in Bahraini type 1 diabetes patients."xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15013978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15013978 |
| http://purl.uniprot.org/citations/15013978 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15013978 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15013978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15013978 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15013978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15013978 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15013978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15013978 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-15013978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15013978 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-15013978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15013978 |