| http://purl.uniprot.org/citations/15014429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15014429 | http://www.w3.org/2000/01/rdf-schema#comment | "Leptospirosis is a zoonosis that can cause severe multisystem disease. While host gene-environment interactions likely modify infectious disease susceptibility, including for leptopsirosis, this has not been documented. In a 1998 leptospirosis outbreak investigation among triathletes in a lake swim, swallowing lake-water was a disease risk-factor. We used genomic DNA from 85 anonymized blood-sample remainders from that investigation to examine the association of laboratory-confirmed leptospirosis with gene polymorphisms (TNF-alpha alleles and serologically defined genotypes for HLA-DRB1 and HLA-DQB1). HLA-DQ6-positive triathletes had increased risk of laboratory-confirmed leptospirosis (OR=2.8, P=0.04) compared to DQ6-negatives. DQ6-positive triathletes swallowing lake-water had greatest risk (OR 8.46, P< or =0.001). This first report of a genetic risk-factor affecting susceptibility to leptospirosis is also the first documented gene-environment interaction (DQ6 and swallowed water) affecting infectious disease susceptibility. Based on these preliminary findings, we hypothesize a role for superantigens in leptospirosis and underscore the importance of outbreak investigations for understanding infectious disease gene-environment interactions."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6364058"xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/author | "Kaiser R."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/author | "Kuffner T."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/author | "McNicholl J."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/author | "Lingappa J."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/author | "Whitworth W."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/author | "Mize A."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/author | "Tappero J."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/pages | "197-202"xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/title | "HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis."xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/15014429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15014429 |
| http://purl.uniprot.org/citations/15014429 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15014429 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15014429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15014429 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15014429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15014429 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-15014429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15014429 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-15014429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15014429 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-15014429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15014429 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-15014429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15014429 |