| http://purl.uniprot.org/citations/15014436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15014436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15014436 | http://www.w3.org/2000/01/rdf-schema#comment | "Thrombospondins (TSPs) are extracellular regulators of cell-matrix interactions and cell phenotype. The most highly conserved region of all TSPs are the calcium-binding type 3 (T3) repeats and the C-terminal globular domain (CTD). The crystal structure of a cell-binding TSP-1 fragment, spanning three T3 repeats and the CTD, reveals a compact assembly. The T3 repeats lack secondary structure and are organised around a core of calcium ions; two DxDxDGxxDxxD motifs per repeat each encapsulate two calcium ions in a novel arrangement. The CTD forms a lectin-like beta-sandwich and contains four strictly conserved calcium-binding sites. Disruption of the hairpin structure of T3 repeats 6 and 7 decreases protein secretion and stability. The availability for cell attachment of an RGD motif in T3 repeat 7 is modulated by calcium loading. The central architectural role of calcium explains how it is critical for the functions of the TSP C-terminal region. Mutations in the T3 repeats of TSP-5/COMP, which cause two human skeletal disorders, are predicted to disrupt the tertiary structure of the T3-CTD assembly."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600166"xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600166"xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/author | "Hohenester E."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/author | "Hohenester E."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/author | "Kvansakul M."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/author | "Kvansakul M."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/author | "Adams J.C."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/author | "Adams J.C."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/pages | "1223-1233"xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/pages | "1223-1233"xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/title | "Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/title | "Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats."xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15014436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15014436 |
| http://purl.uniprot.org/citations/15014436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15014436 |
| http://purl.uniprot.org/citations/15014436 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15014436 |
| http://purl.uniprot.org/citations/15014436 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15014436 |