| http://purl.uniprot.org/citations/15017387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15017387 | http://www.w3.org/2000/01/rdf-schema#comment | "Promyelocytic leukemia nuclear bodies (PML-NBs) comprise multiple regulatory factors and play crucial roles in the maintenance of cellular integrity, while unregulated activation of PML-NBs induces death and premature senescence. Hence, the function of PML-NBs must be directed properly; however, the mechanism that regulates PML-NBs remains unclear. In this paper, we show that PML-NBs are disintegrated by an AT-rich interaction domain family protein E2FBP1/hDril1 through specific desumoylation of promyelocytic leukemia protein (PML) in vivo and in vitro. RNA interference-mediated downregulation of E2FBP1/hDril1 results in hyperplasis of PML-NBs and consequent commitment to PML-dependent premature senescence. Thus, the function of E2FBP1/hDril1 is required for maintenance of survival potential of the cells. Our data suggest a novel mechanism to govern cellular integrity through the modulation of nuclear depots."xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401412"xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/author | "Tsunematsu Y."xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/author | "Mogi K."xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/author | "Fukuyo Y."xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/pages | "747-759"xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/title | "E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies."xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15017387 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15017387 |
| http://purl.uniprot.org/citations/15017387 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15017387 |
| http://purl.uniprot.org/uniprot/#_Q99856-mappedCitation-15017387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15017387 |
| http://purl.uniprot.org/uniprot/Q99856 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15017387 |