| http://purl.uniprot.org/citations/15019597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15019597 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to test the hypothesis that HLA-DRB1, -DQA1, and -DQB1 subgroups or angiotensin-converting enzyme (ACE) gene polymorphisms are associated with severe retinopathy in younger Type 1 diabetic patients. Twenty-four Type 1 diabetic patients who had received panretinal photocoagulation for severe nonproliferative or proliferative diabetic retinopathy were compared with 24 Type 1 diabetic patients (participating in a photographic screening program with regular fundus examinations) with no or minimal retinopathy, matched for age at onset and duration of diabetes. The HLA-DRB1-DQA1-B1 haplotype 04-03-0302 represented 22/48 (46%) in the severe and 21/48 (44%) in the no/minimal retinopathy group, respectively (n.s.). The most common genotype, 03-0501-0201/04-03-0302, occurred in 8/24 (33%) with severe and 10/24 (42%) with no/minimal retinopathy, respectively (n.s.). There were no statistical differences between patients with severe and no/minimal retinopathy whether DRB1, DQA1, or DQB1 alleles, haplotypes, or genotypes were analysed. The ACE gene polymorphism was almost identical between patients with severe and no/minimal retinopathy, and serum ACE levels did not differ. Thus, in the present study on a small group with carefully characterised diabetic retinopathy phenotypes, there was no indication that HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms were associated with severe retinopathy in younger Type 1 diabetic patients."xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1056-8727(03)00040-0"xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/author | "Lernmark A."xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/author | "Gaur L.K."xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/author | "Agardh C.D."xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/author | "Agardh E."xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/name | "J Diabetes Complications"xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/pages | "32-36"xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/title | "HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients."xsd:string |
| http://purl.uniprot.org/citations/15019597 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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