| http://purl.uniprot.org/citations/15020404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15020404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15020404 | http://www.w3.org/2000/01/rdf-schema#comment | "From the time of DNA replication until anaphase onset, sister chromatids remain tightly paired along their length. Ctf7p/Eco1p is essential to establish sister-chromatid pairing during S-phase and associates with DNA replication components. DNA helicases precede the DNA replication fork and thus will first encounter chromatin sites destined for cohesion. In this study, I provide the first evidence that a DNA helicase is required for proper sister-chromatid cohesion. Characterizations of chl1 mutant cells reveal that CHL1 interacts genetically with both CTF7/ECO1 and CTF18/CHL12, two genes that function in sister-chromatid cohesion. Consistent with genetic interactions, Chl1p physically associates with Ctf7p/Eco1p both in vivo and in vitro. Finally, a functional assay reveals that Chl1p is critical for sister-chromatid cohesion. Within the budding yeast genome, Chl1p exhibits the highest degree of sequence similarity to human CHL1 isoforms and BACH1. Previous studies revealed that human CHLR1 exhibits DNA helicase-like activities and that BACH1 is a helicase-like protein that associates with the tumor suppressor BRCA1 to maintain genome integrity. Our findings document a novel role for Chl1p in sister-chromatid cohesion and provide new insights into the possible mechanisms through which DNA helicases may contribute to cancer progression when mutated."xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.166.1.33"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.166.1.33"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/author | "Skibbens R.V."xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/author | "Skibbens R.V."xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/pages | "33-42"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/pages | "33-42"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/title | "Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion."xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/title | "Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion."xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15020404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15020404 |
| http://purl.uniprot.org/citations/15020404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15020404 |
| http://purl.uniprot.org/citations/15020404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15020404 |
| http://purl.uniprot.org/citations/15020404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15020404 |
| http://purl.uniprot.org/uniprot/P43605 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15020404 |
| http://purl.uniprot.org/uniprot/P22516 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15020404 |
| http://purl.uniprot.org/uniprot/P22516#attribution-155DE93A571D6C975D3333328076164A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15020404 |
| http://purl.uniprot.org/uniprot/P22516#attribution-DD3F108B94F054DA8471DCF6BD5799F7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15020404 |