| http://purl.uniprot.org/citations/15020416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15020416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15020416 | http://www.w3.org/2000/01/rdf-schema#comment | "To form the proximal-distal axis of the C. elegans gonad, two somatic gonadal precursor cells, Z1 and Z4, divide asymmetrically to generate one daughter with a proximal fate and one with a distal fate. Genes governing this process include the lin-17 frizzled receptor, wrm-1/beta-catenin, the pop-1/TCF transcription factor, lit-1/nemo-like kinase, and the sys-1 gene. Normally, all of these regulators promote the distal fate. Here we show that nuclear levels of a pop-1 GFP fusion protein are less abundant in the distal than in the proximal Z1/Z4 daughters. This POP-1 asymmetry is lost in mutants disrupting Wnt/MAPK regulation, but retained in sys-1 mutants. We find that sys-1 is haplo-insufficient for gonadogenesis defects and that sys-1 and pop-1 mutants display a strong genetic interaction in double heterozygotes. Therefore, sys-1 is a dose-sensitive locus and may function together with pop-1 to control Z1/Z4 asymmetry. To identify other regulatory genes in this process, we screened for mutants resembling sys-1. Four such genes were identified (gon-14, -15, -16, and sys-3) and shown to interact genetically with sys-1. However, only sys-3 promotes the distal fate at the expense of the proximal fate. We suggest that sys-3 is a new key gene in this pathway and that gon-14, gon-15, and gon-16 may cooperate with POP-1 and SYS-1 at multiple stages of gonad development."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.166.1.171"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.166.1.171"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Siegfried K.R."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Siegfried K.R."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Chesney M.A."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Chesney M.A."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Kidd A.R. III"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/author | "Kidd A.R. III"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/pages | "171-186"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/pages | "171-186"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/title | "The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/title | "The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad."xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15020416 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15020416 |
| http://purl.uniprot.org/citations/15020416 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15020416 |