| http://purl.uniprot.org/citations/15029244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15029244 | http://www.w3.org/2000/01/rdf-schema#comment | "The Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase mediates degradation of cell cycle proteins during mitosis and G1. Cdc20/Fzy and Cdh1/Fzr are substrate-specific APC/C activators. The level of mammalian Cdh1 is high in mitosis, but it is inactive and does not bind the APC/C. We show that when Cdh1 is active in G1 and G0, its levels are considerably lower and almost all of it is APC/C associated. We demonstrate that Cdh1 is subject to APC/C-specific degradation in G1 and G0, and that this degradation depends upon two RXXL-type destruction boxes. We further demonstrate that addition of Cdh1 to Xenopus interphase extracts, which have an inactive APC/C, activates it to degrade Cdh1. These observations indicate that Cdh1 mediates its own degradation by activating the APC/C to degrade itself. Elevated levels of Cdh1 are deleterious for cell cycle progression in various organisms. This auto-regulation of Cdh1 could thus play a role in ensuring that the level of Cdh1 is reduced during G1 and G0, allowing it to be switched off at the correct time."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600149"xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/author | "Mahbubani H.M."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/author | "Lebendiker M."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/author | "Weiss A.M."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/author | "Oren Y.S."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/author | "Listovsky T."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/author | "Brandeis M."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/author | "Yudkovsky Y."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/pages | "1619-1626"xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/title | "Mammalian Cdh1/Fzr mediates its own degradation."xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15029244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15029244 |
| http://purl.uniprot.org/citations/15029244 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15029244 |
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| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-15029244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15029244 |