| http://purl.uniprot.org/citations/15029245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15029245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15029245 | http://www.w3.org/2000/01/rdf-schema#comment | "p140 Ras-GRF1 and p130 Ras-GRF2 constitute a family of calcium/calmodulin-regulated guanine-nucleotide exchange factors that activate the Ras GTPases. Studies on mice lacking these exchange factors revealed that both p140 Ras-GRF1 and p130 Ras-GRF2 couple NMDA glutamate receptors (NMDARs) to the activation of the Ras/Erk signaling cascade and to the maintenance of CREB transcription factor activity in cortical neurons of adult mice. Consistent with this function for Ras-GRFs and the known neuroprotective effect of CREB activity, ischemia-induced CREB activation is reduced in the brains of adult Ras-GRF knockout mice and neuronal damage is enhanced. Interestingly, in cortical neurons of neonatal animals NMDARs signal through Sos rather than Ras-GRF exchange factors, implying that Ras-GRFs endow NMDARs with functions unique to mature neurons."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600151"xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600151"xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Tian X."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Tian X."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Tsuji K."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Tsuji K."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Gotoh T."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Gotoh T."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Feig L.A."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Feig L.A."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Lo E.H."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/author | "Lo E.H."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/pages | "1567-1575"xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/pages | "1567-1575"xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/title | "Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB."xsd:string |
| http://purl.uniprot.org/citations/15029245 | http://purl.uniprot.org/core/title | "Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB."xsd:string |