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| http://purl.uniprot.org/citations/15033536 | http://www.w3.org/2000/01/rdf-schema#comment | "This is the first identification of a long-chain fatty acyl-CoA synthetase in Drosophila by enzymatic characterization. The gene product of CG6178 (CG6178) in Drosophila melanogaster genome, which has a high sequence similarity to firefly luciferase, has been expressed and characterized. CG6178 showed long-chain fatty acyl-CoA synthetic activity in the presence of ATP, CoA and Mg(2+), suggesting a fatty acyl adenylate is an intermediate. Recently, it was revealed that firefly luciferase has two catalytic functions, monooxygenase (luciferase) and AMP-mediated CoA ligase (fatty acyl-CoA synthetase). However, unlike firefly luciferase, CG6178 did not show luminescence activity in the presence of firefly luciferin, ATP, CoA and Mg(2+). The enzymatic properties of CG6178 including substrate specificity, pH dependency and optimal temperature were close to those of firefly luciferase and rat fatty acyl-CoA synthetase. Further, phylogenic analyses strongly suggest that the firefly luciferase gene may have evolved from a fatty acyl-CoA synthetase gene as a common ancestral gene."xsd:string |
| http://purl.uniprot.org/citations/15033536 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2003.12.026"xsd:string |
| http://purl.uniprot.org/citations/15033536 | http://purl.uniprot.org/core/author | "Inouye S."xsd:string |
| http://purl.uniprot.org/citations/15033536 | http://purl.uniprot.org/core/author | "Oba Y."xsd:string |
| http://purl.uniprot.org/citations/15033536 | http://purl.uniprot.org/core/author | "Ojika M."xsd:string |
| http://purl.uniprot.org/citations/15033536 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15033536 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
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| http://purl.uniprot.org/citations/15033536 | http://purl.uniprot.org/core/title | "Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/15033536 | http://purl.uniprot.org/core/volume | "329"xsd:string |
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