| http://purl.uniprot.org/citations/15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15033780 | http://www.w3.org/2000/01/rdf-schema#comment | "Posttranscriptional control of gene expression plays a key role in regulating gene expression in cells undergoing apoptosis. Cyclooxygenase-2 (COX-2) is a crucial enzyme in the conversion of arachidonic acid to prostaglandin E2 (PGE(2)) and is significantly upregulated in many types of adenocarcinomas. COX-2 overexpression leads to increased PGE(2) production, resulting in increased cellular proliferation. PGE(2) enhances the resistance of cells to ionizing radiation. Accordingly, understanding mechanisms regulating COX-2 expression may lead to important therapeutic advances. Besides transcriptional control, COX-2 expression is significantly regulated by mRNA stability and translation. We have previously demonstrated that RNA binding protein CUGBP2 binds AU-rich sequences to regulate COX-2 mRNA translation. In the current study, we have determined that expression of both COX-2 mRNA and CUGBP2 mRNA are induced in MCF-7 cells, a breast cancer cell line, following exposure to 12 Gy gamma-irradiation. However, only CUGBP2 protein is induced, but COX-2 protein levels were not altered. Silencer RNA (siRNA)-mediated inhibition of CUGBP2 reversed the block in COX-2 protein expression. Furthermore, MCF-7 cells underwent apoptosis in response to radiation injury, which was also reversed by CUGBP2 siRNAs. These data suggest that CUGBP2 is a critical regulator of the apoptotic response to genotoxic injury in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.org/dc/terms/identifier | "doi:10.1196/annals.1299.093"xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/author | "Anant S."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/author | "Mukhopadhyay D."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/author | "Dieckgraefe B.K."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/author | "Houchen C.W."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/author | "Murmu N."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/pages | "504-509"xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/title | "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury."xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://purl.uniprot.org/core/volume | "1010"xsd:string |
| http://purl.uniprot.org/citations/15033780 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15033780 |
| http://purl.uniprot.org/citations/15033780 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15033780 |
| http://purl.uniprot.org/uniprot/#_E9PC62-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GU44-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GUN8-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YX66-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YXJ0-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_B4DDE7-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_B4DIB6-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_B4DM66-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |
| http://purl.uniprot.org/uniprot/#_B4DMB0-mappedCitation-15033780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15033780 |