| http://purl.uniprot.org/citations/15034021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15034021 | http://www.w3.org/2000/01/rdf-schema#comment | "Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) is a member of the signal regulatory protein family in which the extracellular region interacts with its ligand, CD47. Recent studies have demonstrated that SHPS-1 plays an important role in cell migration and cell adhesion. We demonstrate in this study, using immunohistochemical and flow cytometric analyses, that murine Langerhans cells (LCs) express SHPS-1. Treatment of mice ears with 2,4-dinitro-1-fluorobenzene significantly reduced the number of epidermal LCs, and that reduction could be reversed by pretreatment with mAb to SHPS-1 or the CD47-Fc fusion protein. Treatment with the SHPS-1 mAb in vivo reduced the number of FITC-bearing cells in the lesional lymph nodes after the application of FITC to the skin. The SHPS-1 mAb inhibited the in vivo TNF-alpha-induced migration of LCs. The emigration of dendritic cells expressing I-A(b+) from skin explants to the medium was also reduced by the SHPS-1 mAb. We further demonstrate that the chemotaxis of a murine dendritic cell line, XS52, by macrophage inflammatory protein-3beta was significantly inhibited by treatment with the SHPS-1 mAb or CD47-Fc recombinant protein. Finally, we show that migration of LCs was attenuated in mutant mice that lack the intracellular domain of SHPS-1. These observations show that the ligation of SHPS-1 with the SHPS-1 mAb or with CD47-Fc abrogates the migration of LCs in vivo and in vitro, which suggests that the SHPS-1-CD47 interaction may negatively regulate LC migration."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.7.4091"xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Kasuga M."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Nagai H."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Noguchi T."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Okazawa H."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Fukunaga A."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Lagenaur C.F."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Honma N."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Matozaki T."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Horikawa T."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Nishigori C."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/author | "Ichihashi M."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/pages | "4091-4099"xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/title | "Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes."xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/15034021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15034021 |
| http://purl.uniprot.org/citations/15034021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15034021 |
| http://purl.uniprot.org/uniprot/#_A2ANC1-mappedCitation-15034021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15034021 |
| http://purl.uniprot.org/uniprot/#_E0CX65-mappedCitation-15034021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15034021 |
| http://purl.uniprot.org/uniprot/#_P97797-mappedCitation-15034021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15034021 |