| http://purl.uniprot.org/citations/15034066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15034066 | http://www.w3.org/2000/01/rdf-schema#comment | "Neutrophil elastase (NE) remains a controversial player in the process of leukocyte transmigration and much of this controversy stems from conflicting reports on the effects of NE inhibitors. The availability of NE-deficient mice (NE(-/-)) provides a clean and elegant tool for the study of leukocyte migration in vivo. In this study, NE(-/-) mice were used to investigate the role of NE in leukocyte migration through cremasteric venules, as observed by intravital microscopy, induced by locally administered cytokines IL-1beta and TNF-alpha and the particulate stimulus, zymosan. Although no defects in leukocyte responses induced by the cytokines were observed, zymosan-induced leukocyte firm adhesion and transmigration was suppressed in NE(-/-) mice. These responses were also inhibited in wild-type mice when zymosan was coinjected with a specific NE inhibitor. Quantification of inflammatory mediator levels in homogenates of zymosan-stimulated tissues indicated reductions in levels of IL-1beta, KC, and macrophage inflammatory protein-1alpha in NE(-/-) mice. Furthermore, phagocytosis of fluorescent zymosan particles, as observed by intravital microscopy, was diminished in NE-deficient animals. Collectively, the findings of this study indicate a nonredundant role for NE in zymosan-induced leukocyte firm adhesion and transmigration, and that this defect is associated with impaired generation of proinflammatory mediators as well as phagocytosis of zymosan particles in vivo."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.7.4493"xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "Perretti M."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "La M."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "Thompson R.D."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "Shapiro S.D."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "Young R.E."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "Nourshargh S."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "Larbi K.Y."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/author | "Roberts C.E."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/pages | "4493-4502"xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/title | "Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo."xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/15034066 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15034066 |
| http://purl.uniprot.org/citations/15034066 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15034066 |
| http://purl.uniprot.org/uniprot/Q3UP87#attribution-5FC6F71BD6865447B891BB9AF7D092B6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15034066 |
| http://purl.uniprot.org/uniprot/P10749#attribution-DEB59F50FA69F9360524B91DD2F55609 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15034066 |
| http://purl.uniprot.org/uniprot/P06804#attribution-DEB59F50FA69F9360524B91DD2F55609 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15034066 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-15034066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15034066 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-15034066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15034066 |
| http://purl.uniprot.org/uniprot/#_Q3TI17-mappedCitation-15034066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15034066 |
| http://purl.uniprot.org/uniprot/#_Q3U593-mappedCitation-15034066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15034066 |