| http://purl.uniprot.org/citations/15034551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15034551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15034551 | http://www.w3.org/2000/01/rdf-schema#comment | "The exon junction complex (EJC), a set of proteins deposited on mRNAs as a consequence of pre-mRNA splicing, is a key effector of downstream mRNA metabolism. We have identified eIF4AIII, a member of the eukaryotic translation initiation factor 4A family of RNA helicases (also known as DExH/D box proteins), as a novel EJC core component. Crosslinking and antibody inhibition studies suggest that eIF4AIII constitutes at least part of the platform anchoring other EJC components to spliced mRNAs. A nucleocytoplasmic shuttling protein, eIF4AIII associates in vitro and in vivo with two other EJC core factors, Y14 and Magoh. In mammalian cells, eIF4AIII is essential for nonsense-mediated mRNA decay (NMD). Finally, a model is proposed by which eIF4AIII represents a new functional class of DExH/D box proteins that act as RNA clamps or 'place holders' for the sequence-independent attachment of additional factors to RNAs."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb750"xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb750"xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Moore M.J."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Moore M.J."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Shibuya T."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Shibuya T."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Tange T.O."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/author | "Tange T.O."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/pages | "346-351"xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/pages | "346-351"xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/title | "eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/title | "eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay."xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15034551 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15034551 |
| http://purl.uniprot.org/citations/15034551 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15034551 |