| http://purl.uniprot.org/citations/15035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15035620 | http://www.w3.org/2000/01/rdf-schema#comment | "The secretion of lung surfactant in alveolar type II cells is a complex process involving the fusion of lamellar bodies with the plasma membrane. This process is somewhat different from the exocytosis of hormones and neurotransmitters. For example, it is a relatively slower process, and lamellar bodies are very large vesicles with a diameter of approximately 1 microm. SNARE proteins are the conserved molecular machinery of exocytosis in the majority of secretory cells. However, their involvement in surfactant secretion has not been reported. Here, we showed that syntaxin 2 and SNAP-23 are expressed in alveolar type II cells. Both proteins are associated with the plasma membrane, and to some degree with lamellar bodies. An antisense oligonucleotide complementary to syntaxin 2 decreased its mRNA and protein levels. The same oligonucleotide also inhibited surfactant secretion, independent of secretagogues. A peptide derived from the N-terminus of syntaxin 2 or the C-terminus of SNAP-23 significantly inhibited Ca(2+)- and GTPgammaS-stimulated surfactant secretion from permeabilized type II cells in a dose-dependent manner. Furthermore, introduction of anti-syntaxin 2 or anti-SNAP-23 antibodies into permeabilized type II cells also inhibited surfactant release. Our results suggest that syntaxin 2 and SNAP-23 are required for regulated surfactant secretion."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi036338y"xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/author | "Gou D."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/author | "Narasaraju T."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/author | "Abonyo B.O."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/pages | "3499-3506"xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/title | "Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion."xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/15035620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15035620 |
| http://purl.uniprot.org/citations/15035620 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15035620 |
| http://purl.uniprot.org/uniprot/#_A6I9V0-mappedCitation-15035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15035620 |
| http://purl.uniprot.org/uniprot/#_P61265-mappedCitation-15035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15035620 |
| http://purl.uniprot.org/uniprot/A6I9V0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15035620 |
| http://purl.uniprot.org/uniprot/P61265 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15035620 |