| http://purl.uniprot.org/citations/15046865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15046865 | http://www.w3.org/2000/01/rdf-schema#comment | "The nocturnal biosynthesis of melatonin in the rat pineal depends on strongly enhanced expression of the enzyme N-acetyltransferase [arylalkylamine N-acetyltransferase (AA-NAT); EC 2.3.1.87]. AA-NAT transcription is stimulated during darkness by adrenergic inputs to the pineal from the suprachiasmatic nucleus (SCN). Nocturnal activation of the AA-NAT promotor following stimulation of pinealocyte adrenoceptors involves cAMP-dependent stimulation of protein kinase A (PKA). The nocturnal rise in AA-NAT depends on the lighting conditions. As compared with light/dark (LD) 12:12, the delay between dark onset and the nocturnal rise in AA-NAT is shortened under long photoperiods and prolonged under short photoperiods. Here, we report that the rapidity of nocturnal AA-NAT induction depends on cAMP inducibility of the gene. Accordingly, cAMP produces a strong AA-NAT response in pineals obtained from rats housed under long photoperiods and a weak AA-NAT response under short photoperiods. Changes in AA-NAT inducibility are fully developed not earlier than after seven cycles. This observation suggests that long-term changes in the photoperiod are necessary to achieve full adjustment of cAMP inducibility of the gene. A direct relationship was found between cAMP-dependent AA-NAT inducibility and the pineal protein kinase A (PKA) activity. As compared to LD 12:12, PKA activity was increased under LD 20:4 and attenuated under LD 4:20. On the basis of the present findings, we suggest that the photoperiod determines the effectiveness of nocturnal AA-NAT induction by long-term modulation of the intrapineal pathway that transmits the cAMP signal to the AA-NAT gene."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molbrainres.2003.12.017"xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Heinrich B."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Spessert R."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Vollrath L."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Engel L."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Holthues H."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Mathes A."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Pogorzelski B."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/author | "Schwerdtle I."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/pages | "45-55"xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/title | "Rat pineal arylalkylamine-N-acetyltransferase: cyclic AMP inducibility of its gene depends on prior entrained photoperiod."xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/15046865 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15046865 |
| http://purl.uniprot.org/citations/15046865 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15046865 |
| http://purl.uniprot.org/uniprot/#_A6HKX7-mappedCitation-15046865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15046865 |
| http://purl.uniprot.org/uniprot/#_Q64666-mappedCitation-15046865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15046865 |
| http://purl.uniprot.org/uniprot/A6HKX7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15046865 |
| http://purl.uniprot.org/uniprot/Q64666 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15046865 |