| http://purl.uniprot.org/citations/15047631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15047631 | http://www.w3.org/2000/01/rdf-schema#comment | "Polymorphism of the insulin gene (INS) variable number of tandem repeats (VNTR; class I or class III alleles) locus has been associated with adult diseases and with birth size. Therefore, this variant is a potential contributory factor to the reported fetal origins of adult disease. In the population-based Avon Longitudinal Study of Pregnancy and Childhood birth cohort, we have confirmed in the present study the association between the INS VNTR III/III genotype and larger head circumference at birth (odds ratio [OR] 1.92, 95% CI 1.23-3.07; P = 0.004) and identified an association with higher cord blood IGF-II levels (P = 0.05 to 0.0001). The genotype association with head circumference was influenced by maternal parity (birth order): the III/III OR for larger head circumference was stronger in second and subsequent pregnancies (OR 5.0, 95% CI 2.2-11.5; P = 0.00003) than in first pregnancies (1.2, 0.6-2.2; P = 0.8; interaction with birth order, P = 0.02). During childhood, the III/III genotype remained associated with larger head circumference (P = 0.004) and was also associated with greater BMI (P = 0.03), waist circumference (P = 0.03), and higher fasting insulin levels in girls (P = 0.02). In addition, there were interactions between INS VNTR genotype and early postnatal weight gain in determining childhood BMI (P = 0.001 for interaction), weight (P = 0.005), and waist circumference (P = 0.0005), such that in the approximately 25% of children (n = 286) with rapid early postnatal weight gain, class III genotype-negative children among this group gained weight more rapidly. Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.org/dc/terms/identifier | "doi:10.2337/diabetes.53.4.1128"xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Todd J.A."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Dunger D.B."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Ring S."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Cordell H.J."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Pembrey M.E."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Barratt B.J."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Ong K.K."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Petry C.J."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/author | "Wingate D.L."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/pages | "1128-1133"xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/title | "Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain."xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/15047631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15047631 |
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