| http://purl.uniprot.org/citations/15050649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15050649 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1beta (IL-1beta) plays a major role in the initiation and exacerbation of brain inflammation, and its action is limited by the natural antagonist of IL-1 receptors, IL-1Ra. The aim of the present study was to test the hypothesis that IL-1beta mediates the functional consequences of inflammation during the course of delayed-type hypersensitivity response to bacillus Calmette-Guérin (BCG) in the hippocampus of Lewis rats. Animals were primed with an injection of BCG in the right hippocampus and challenged 4 weeks later with BCG administered subcutaneously. Concentrations of IL-1beta and IL-1Ra were measured by ELISA in the BCG injected hippocampus and compared to those measured in the contralateral hippocampus during the first 2 weeks post-challenge. IL-1beta levels increased in response to BCG challenge and peaked 12 days after challenge. The same variations appeared in the contralateral hippocampus but to a lesser extent. Hippocampal IL-1Ra levels increased in response to intrahippocampal injection of BCG. They further increased at days 6 and 9 post-challenge and decreased from day 12 back to baseline values on day 16. The increase in IL-1beta levels and the decline in IL-1Ra levels were associated with an impairment in spatial memory in a Y-maze on day 16 post-challenge, that was abrogated by chronic administration of IL-1Ra via a subcutaneously implanted osmotic minipump geared to deliver 7 mg IL-1Ra/day. These results show that overexpression of IL-1beta in the brain during the course of a chronic inflammation has deleterious consequences on cognitive processes, that are reversed by blockade of IL-1 receptors."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbi.2003.09.002"xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/author | "Verrier D."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/author | "Dantzer R."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/author | "Bluthe R.M."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/author | "Palin K."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/author | "Tridon V."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/author | "Lestage J."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/name | "Brain Behav Immun"xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/pages | "223-230"xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/title | "Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guerin in the rat hippocampus."xsd:string |
| http://purl.uniprot.org/citations/15050649 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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