| http://purl.uniprot.org/citations/15050920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15050920 | http://www.w3.org/2000/01/rdf-schema#comment | "8p11 myeloproliferative syndrome (EMS) is a hematopoietic stem cell disorder characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, most commonly ZNF198, to fibroblast growth factor receptor-1 (FGFR1). However, patients with BCR-FGFR1 fusion present with typical chronic myeloid leukemia (CML). We demonstrate that ZNF198-FGFR1 induces EMS-like disease in mice, with myeloproliferation and T lymphoma arising from common multipotential progenitors. Mutation of FGFR1 Tyr766 attenuates both myeloid and lymphoid diseases, identifying phospholipase C-gamma1 as a downstream effector. Bcr-FGFR1 binds Grb2 via Bcr Tyr177 and induces CML-like leukemia in mice, whereas Bcr-FGFR1/Y177F lacks Grb2 binding and causes EMS-like disease. These results implicate different signaling pathways originating from both kinase and fusion partner in the pathogenesis of CML and EMS."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1535-6108(04)00053-4"xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/author | "Van Etten R.A."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/author | "Cross N.C."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/author | "Krause D.S."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/author | "Neumann C.A."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/author | "Dimitri C.A."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/author | "Roumiantsev S."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/author | "Asiedu F."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/pages | "287-298"xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/title | "Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations."xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/15050920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15050920 |
| http://purl.uniprot.org/citations/15050920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15050920 |
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| http://purl.uniprot.org/uniprot/#_P09038-mappedCitation-15050920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15050920 |
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| http://purl.uniprot.org/uniprot/#_P39880-mappedCitation-15050920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15050920 |
| http://purl.uniprot.org/uniprot/#_Q16630-mappedCitation-15050920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15050920 |