Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/15051600http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15051600http://www.w3.org/2000/01/rdf-schema#comment"

Background

Decreased fibrinolytic activity is associated with an increased risk of ischemic heart disease and elevated plasma triacylglycerol concentrations.

Objective

The goal was to determine whether plasminogen activator inhibitor 1 (PAI-1) and fibrinolytic activities are influenced by 1) dietary fat intake from a test meal and 2) the PAI-1 4G allele.

Design

A parallel randomized controlled trial was used to compare the effect on fibrinolytic activity, measured as dilute clot lysis time, of high-oleate or high-palmitate test meals (both containing 50 g fat; both n = 18) with that of a low-fat test meal (15 g fat; n = 15) in men aged > 52 y. In a second study, postprandial changes in PAI-1 activity were measured in 32 men in response to a high-oleate meal containing 50 g fat. The results from both studies were analyzed according to PAI-1 4G-675/5G genotype.

Results

Fasting dilute clot lysis time was positively associated with body mass index (r = 0.326, P = 0.02) and was shortened postprandially (P < 0.00001) independent of the fat content of the meal. Fasting PAI-1 activity was higher in those carrying the 4G allele and was correlated with fasting plasma triacylglycerol concentrations (r = 0.48, P = 0.008) and factor VII coagulant activity (r = 0.46, P = 0.012) after adjustments for age, body mass index, and genotype. Plasma PAI-1 activity decreased significantly after a meal but was not associated with postprandial changes in plasma triacylglycerols after a high-fat meal. The postprandial increase in plasma triacylglycerols was higher in subjects carrying the 4G allele.

Conclusion

Fibrinolytic activity is not lower after meals rich in palmitate or oleate than after a low-fat meal."xsd:string
http://purl.uniprot.org/citations/15051600http://purl.org/dc/terms/identifier"doi:10.1093/ajcn/79.4.577"xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/author"Miller G.J."xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/author"Humphries S.E."xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/author"Sanders T.A."xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/author"Acharya J."xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/author"de Grassi T."xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/name"Am J Clin Nutr"xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/pages"577-581"xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/title"Postprandial variations in fibrinolytic activity in middle-aged men are modulated by plasminogen activator inhibitor I 4G-675/5G genotype but not by the fat content of a meal."xsd:string
http://purl.uniprot.org/citations/15051600http://purl.uniprot.org/core/volume"79"xsd:string
http://purl.uniprot.org/citations/15051600http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15051600
http://purl.uniprot.org/citations/15051600http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15051600
http://purl.uniprot.org/uniprot/#_A0A5B9RUH0-mappedCitation-15051600http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/#_B7Z1D9-mappedCitation-15051600http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/#_B7Z4X6-mappedCitation-15051600http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/#_B7ZAB0-mappedCitation-15051600http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/#_P05121-mappedCitation-15051600http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/B7ZAB0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/P05121http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/A0A5B9RUH0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/B7Z4X6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15051600
http://purl.uniprot.org/uniprot/B7Z1D9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15051600
▶