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| http://purl.uniprot.org/citations/15051737 | http://www.w3.org/2000/01/rdf-schema#comment | "By screening for mutants exhibiting interactions with a dominant-negative dynamin, we have identified the Drosophila homologue of receptor-mediated endocytosis (Rme) 8, a J-domain-containing protein previously shown to be required for endocytosis in Caenorhabditis elegans. Analysis of Drosophila Rme-8 mutants showed that internalization of Bride of sevenless and the uptake of tracers were blocked. In addition, endosomal organization and the distribution of clathrin were greatly disrupted in Rme-8 cells, suggesting that Rme-8 participates in a clathrin-dependent process. The phenotypes of Rme-8 mutants bear a strong resemblance to those of Hsc70-4, suggesting that these two genes act in a common pathway. Indeed, biochemical and genetic data demonstrated that Rme-8 interacts specifically with Hsc70-4 via its J-domain. Thus, Rme-8 appears to function as an unexpected but critical cochaperone with Hsc70 in endocytosis. Because Hsc70 is known to act in clathrin uncoating along with auxilin, another J-protein, its interaction with Rme-8 indicates that Hsc70 can act with multiple cofactors, possibly explaining its pleiotropic effects on the endocytic pathway."xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200311084"xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/author | "Chang H.C."xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/author | "Mellman I."xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/author | "Hull M."xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/pages | "1055-1064"xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/title | "The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/15051737 | http://purl.uniprot.org/core/volume | "164"xsd:string |
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