| http://purl.uniprot.org/citations/15052269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15052269 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic variation at the human LTA locus, encoding lymphotoxin-alpha, is associated with susceptibility to myocardial infarction, asthma and other diseases. By detailed haplotypic analysis of the locus, we identified a single-nucleotide polymorphism (SNP) at LTA+80 as a main predictor of LTA protein production by human B cells. We found that activated B-cell factor-1 (ABF-1) binds to this site in vitro and suppresses reporter gene expression, but only in the presence of the LTA+80A allele. Using haplotype-specific chromatin immunoprecipitation, we confirmed that ABF-1 is preferentially recruited to the low-producer allele in vivo. These findings provide a molecular model of how LTA expression may be genetically regulated by allele-specific recruitment of the transcriptional repressor ABF-1."xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1331"xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/author | "Knight J.C."xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/author | "Kwiatkowski D.P."xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/author | "Keating B.J."xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/pages | "394-399"xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/title | "Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1."xsd:string |
| http://purl.uniprot.org/citations/15052269 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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