| http://purl.uniprot.org/citations/15053874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15053874 | http://www.w3.org/2000/01/rdf-schema#comment | "A puzzling observation in patients with oxidative phosphorylation (OXPHOS) deficiencies is the presence of combined enzyme complex defects associated with a genetic alteration in only one protein-coding gene. In particular, mutations in the mtDNA encoded cytochrome b gene are associated either with combined complex I+III deficiency or with only complex III deficiency. We have reproduced the combined complex I+III defect in mouse and human cultured cell models harboring cytochrome b mutations. In both, complex III assembly is impeded and causes a severe reduction in the amount of complex I, not observed when complex III activity was pharmacologically inhibited. Metabolic labeling in mouse cells revealed that complex I was assembled, although its stability was severely hampered. Conversely, complex III stability was not influenced by the absence of complex I. This structural dependence among complexes I and III was confirmed in a muscle biopsy of a patient harboring a nonsense cytochrome b mutation."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(04)00124-8"xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Moraes C.T."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Bruno C."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Fernandez-Silva P."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Acin-Perez R."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Bayona-Bafaluy M.P."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Enriquez J.A."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Moreno-Loshuertos R."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/author | "Perez-Martos A."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/pages | "805-815"xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/title | "Respiratory complex III is required to maintain complex I in mammalian mitochondria."xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/15053874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15053874 |
| http://purl.uniprot.org/citations/15053874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15053874 |
| http://purl.uniprot.org/uniprot/Q9QZQ8#attribution-CC8630E1C2C837C96318D967554DA547 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15053874 |
| http://purl.uniprot.org/uniprot/O75367#attribution-B34756EAE617FB2EBEC7BC9B401A5AD5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15053874 |
| http://purl.uniprot.org/uniprot/#_Q3V2F9-mappedCitation-15053874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15053874 |
| http://purl.uniprot.org/uniprot/#_Q3UQD2-mappedCitation-15053874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15053874 |
| http://purl.uniprot.org/uniprot/#_Q7JCY4-mappedCitation-15053874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15053874 |
| http://purl.uniprot.org/uniprot/#_Q7JCZ3-mappedCitation-15053874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15053874 |
| http://purl.uniprot.org/uniprot/#_Q9QZQ8-mappedCitation-15053874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15053874 |