| http://purl.uniprot.org/citations/15057044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15057044 | http://www.w3.org/2000/01/rdf-schema#comment | "Intratumoral vessels are different both structurally and phenotypically, and this may have clinical significance. In this study we analysed the expression of an adhesion molecule--vascular adhesion protein-1 (VAP-1)--in melanoma-associated blood vessels in 28 primary skin melanoma cases using immunocytochemistry and immunoelectron microscopy. We have found that VAP-1 protein expression is significantly decreased in intratumoral vessels compared with peritumoral ones; this difference was independent of the tumour thickness. Loss of VAP-1 protein expression occurred in both endothelial and smooth muscle cell components. Unlike in other cancer types, the VAP-1 protein expression of intratumoral vessels did not correlate with the density of cytotoxic T-lymphocytes or dendritic cells. On the other hand, the 5-year survival of melanoma patients with low VAP-1 protein expression in intratumoral blood vessels (< or =25%) was lower (26.3%) than in patients whose VAP-1 expression was higher (42.6%, P=0.0632). These results support the idea that the phenotype of intratumoral blood vessels is important in the progression of malignant melanoma."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.org/dc/terms/identifier | "doi:10.1097/00008390-200404000-00010"xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/author | "Jalkanen S."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/author | "Timar J."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/author | "Paku S."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/author | "Dome B."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/author | "Ladanyi A."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/author | "Somlai B."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/author | "Forster-Horvath C."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/name | "Melanoma Res"xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/pages | "135-140"xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/title | "Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma."xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15057044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15057044 |
| http://purl.uniprot.org/citations/15057044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15057044 |
| http://purl.uniprot.org/uniprot/#_Q16853-mappedCitation-15057044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15057044 |
| http://purl.uniprot.org/uniprot/#_Q9UEU7-mappedCitation-15057044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15057044 |
| http://purl.uniprot.org/uniprot/Q16853 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15057044 |
| http://purl.uniprot.org/uniprot/Q9UEU7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15057044 |