| http://purl.uniprot.org/citations/15057824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15057824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15057824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15057824 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosome 19 has the highest gene density of all human chromosomes, more than double the genome-wide average. The large clustered gene families, corresponding high G + C content, CpG islands and density of repetitive DNA indicate a chromosome rich in biological and evolutionary significance. Here we describe 55.8 million base pairs of highly accurate finished sequence representing 99.9% of the euchromatin portion of the chromosome. Manual curation of gene loci reveals 1,461 protein-coding genes and 321 pseudogenes. Among these are genes directly implicated in mendelian disorders, including familial hypercholesterolaemia and insulin-resistant diabetes. Nearly one-quarter of these genes belong to tandemly arranged families, encompassing more than 25% of the chromosome. Comparative analyses show a fascinating picture of conservation and divergence, revealing large blocks of gene orthology with rodents, scattered regions with more recent gene family expansions and deletions, and segments of coding and non-coding conservation with the distant fish species Takifugu."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02399"xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02399"xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02399"xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Copeland A."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Copeland A."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Copeland A."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Pitluck S."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Pitluck S."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Pitluck S."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Nolan M."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Nolan M."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Nolan M."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Tice H."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Tice H."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Tice H."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Aerts A."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Aerts A."xsd:string |
| http://purl.uniprot.org/citations/15057824 | http://purl.uniprot.org/core/author | "Aerts A."xsd:string |