| http://purl.uniprot.org/citations/15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15059847 | http://www.w3.org/2000/01/rdf-schema#comment | "Engagement of the T-cell receptor (TCR) results in the activation of Lck/Fyn and ZAP-70/Syk tyrosine kinases. Lck-mediated tyrosine phosphorylation of signaling motifs (ITAMs) in the CD3-zeta subunits of the TCR is an initial step in the transduction of signaling cascades. However, zeta phosphorylation is also promoted by ZAP-70, as TCR-induced zeta phosphorylation is defective in ZAP-70-deficient T cells. We show that this defect is corrected by stable expression of ZAP-70, but not Syk, in primary and transformed T cells. Indeed, these proteins are differentially coupled to the TCR with a 5-to 10-fold higher association of ZAP-70 with zeta as compared to Syk. Low-level Syk-zeta binding is associated with significantly less Lck coupled to the TCR. Moreover, diminished coupling of Lck to zeta correlates with a poor phosphorylation of the positive regulatory tyr352 residue of Syk. Thus, recruitment of Lck into the TCR complex with subsequent zeta chain phosphorylation is promoted by ZAP-70 but not Syk. Importantly, the presence of ZAP-70 positively regulates the TCR-induced tyrosine phosphorylation of Syk. The interplay between Syk and ZAP-70 in thymocytes, certain T cells, and B-chronic lymphocytic leukemia cells, in which they are coexpressed, will therefore modulate the amplitude of antigen-mediated receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-12-4314"xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Taylor N."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Merida P."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Pelletier L."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Noraz N."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Di Bartolo V."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Steinberg M."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Swainson L."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/author | "Adjali O."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/pages | "760-767"xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/title | "T-cell receptor-induced phosphorylation of the zeta chain is efficiently promoted by ZAP-70 but not Syk."xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/15059847 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15059847 |
| http://purl.uniprot.org/citations/15059847 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15059847 |
| http://purl.uniprot.org/uniprot/#_A8K4G2-mappedCitation-15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059847 |
| http://purl.uniprot.org/uniprot/#_B3KQJ1-mappedCitation-15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059847 |
| http://purl.uniprot.org/uniprot/#_C3W980-mappedCitation-15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059847 |
| http://purl.uniprot.org/uniprot/#_C3W981-mappedCitation-15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059847 |
| http://purl.uniprot.org/uniprot/#_B4E0E2-mappedCitation-15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059847 |
| http://purl.uniprot.org/uniprot/#_Q13196-mappedCitation-15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059847 |
| http://purl.uniprot.org/uniprot/#_P43403-mappedCitation-15059847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059847 |