| http://purl.uniprot.org/citations/15059932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15059932 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite advances in the molecular biology of cardiac myosin binding protein-C (cMyBP-C), little is understood about its precise role in muscle contraction, particularly in the intact heart. We tested the hypothesis that cMyBP-C is central to the time course and magnitude of left ventricular systolic elastance (chamber stiffening), and assessed mechanisms for this influence in intact hearts, trabeculae, and skinned fibers from wild-type (+/+) and homozygous truncated cMyBP-C (t/t) male mice. cMyBP-C protein was not detected by gel electrophoresis or Western blot in t/t myocardium. cMyBP-C t/t ventricles displayed reduced peak elastance, but more strikingly a marked abbreviation of the systolic elastance time course, which peaked earlier (27.6+/-2.1 ms) than in +/+ controls (47.8+/-1.6 ms). Control hearts reached only 42+/-4% of maximum elastance at the onset of ejection, with substantial further stiffening during ejection. This contrasted to t/t mutants, which reached 77+/-3% of peak elastance before ejection of peak. These unusual findings were not observed in alternative models involving severe cardiomyopathy, but were recapitulated in a cMyBP-C null mouse. The abbreviated elastance time course and lower peak were consistent with earlier time-to-peak trabecular tension, increased unloaded shortening velocity in t/t skinned muscle strips, and dramatically reduced myofilament stiffness at diastolic calcium concentrations. These results provide novel insights into the role of cMyBP-C in myocardial systolic mechanics. Abnormal sarcomere shortening velocity and abbreviated muscle stiffening may underlie development of cardiac dysfunction associated with deficient incorporation of cMyBP-C."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000126898.95550.31"xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Burgon P.G."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Seidman C.E."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Seidman J.G."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Georgakopoulos D."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Alpert N.R."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Moss R.L."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Kass D.A."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Janssen P.M."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Maughan D.W."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Harris S.P."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Palmer B.M."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/author | "Belardi D.F."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/pages | "1249-1255"xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/title | "Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening."xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/15059932 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15059932 |
| http://purl.uniprot.org/citations/15059932 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15059932 |
| http://purl.uniprot.org/uniprot/O70468#attribution-0BF630543D9CC5D46118EFE70AFC3D52 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15059932 |
| http://purl.uniprot.org/uniprot/#_E9Q9T8-mappedCitation-15059932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15059932 |