| http://purl.uniprot.org/citations/15060089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15060089 | http://www.w3.org/2000/01/rdf-schema#comment | "The tricarboxylate (citrate) carrier (TCC), a protein of the mitochondrial inner membrane, is an obligatory component of the shuttle system by which mitochondrial acetyl-CoA is transported into the cytosol, where lipogenesis occurs. The aim of this study was to investigate the molecular basis for the regulation of TCC gene expression by a high-fat, n-6 PUFA-enriched diet. Rats received for up to 4 weeks a diet enriched with 15% safflower oil (SO), which is high in linoleic acid (70.4%). We found a gradual decrease of TCC activity and a parallel decline in the abundance of TCC mRNA, the maximum effect occurring after 4 weeks of treatment. At this time, the estimated half-life of TCC mRNA was the same in the hepatocytes from rats on both diets, whereas the transcriptional rate of TCC mRNA, tested by nuclear run-on assay, was reduced by approximately 38% in the rats on the SO-enriched diet. The RNase protection assay showed that the ratio of mature to precursor RNA, measured in the nuclei, decreased with the change to the n-6 PUFA diet. These results suggest that administration of n-6 PUFAs to rats leads to changes not only in the transcriptional rate of the TCC gene but also in the processing of the nuclear precursor for TCC RNA."xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m400061-jlr200"xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/author | "Siculella L."xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/author | "Damiano F."xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/author | "Gnoni G.V."xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/author | "Sabetta S."xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/pages | "1333-1340"xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/title | "n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms."xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/15060089 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15060089 |
| http://purl.uniprot.org/citations/15060089 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15060089 |
| http://purl.uniprot.org/uniprot/#_A6JSJ3-mappedCitation-15060089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15060089 |
| http://purl.uniprot.org/uniprot/#_A6JSJ4-mappedCitation-15060089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15060089 |
| http://purl.uniprot.org/uniprot/#_P32089-mappedCitation-15060089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15060089 |
| http://purl.uniprot.org/uniprot/A6JSJ3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15060089 |
| http://purl.uniprot.org/uniprot/P32089 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15060089 |
| http://purl.uniprot.org/uniprot/A6JSJ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15060089 |