| http://purl.uniprot.org/citations/15062093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15062093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15062093 | http://www.w3.org/2000/01/rdf-schema#comment | "Human fibrillin-1, the major structural protein of extracellular matrix (ECM) 10-12 nm microfibrils, is dominated by 43 calcium binding epidermal growth factor-like (cbEGF) and 7 transforming growth factor beta binding protein-like (TB) domains. Crystal structures reveal the integrin binding cbEGF22-TB4-cbEGF23 fragment of human fibrillin-1 to be a Ca(2+)-rigidified tetragonal pyramid. We suggest that other cbEGF-TB pairs within the fibrillins may adopt a similar orientation to cbEGF22-TB4. In addition, we have located a flexible RGD integrin binding loop within TB4. Modeling, cell attachment and spreading assays, immunocytochemistry, and surface plasmon resonance indicate that cbEGF22 bound to TB4 is a requirement for integrin activation and provide insight into the molecular basis of the fibrillin-1 interaction with alphaVbeta3. In light of our data, we propose a novel model for the assembly of the fibrillin microfibril and a mechanism to explain its extensibility."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.02.023"xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.02.023"xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Grimes J.M."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Grimes J.M."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Lee S.S."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Lee S.S."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Harlos K."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Harlos K."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Handford P.A."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Handford P.A."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Knott V."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Knott V."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Choulier L."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Choulier L."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Jovanovic J."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Jovanovic J."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Mardon H.J."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/author | "Mardon H.J."xsd:string |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15062093 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |