| http://purl.uniprot.org/citations/15066285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15066285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15066285 | http://www.w3.org/2000/01/rdf-schema#comment | "In C. elegans embryos, a Wnt/MAPK signaling pathway downregulates the TCF/LEF transcription factor POP-1, resulting in a lower nuclear level in signal-responsive cells compared to their sisters. Although the beta-catenin WRM-1 is required for POP-1 downregulation, a direct interaction between these two proteins does not seem to be required, as the beta-catenin-interacting domain of POP-1 is dispensable for both POP-1 downregulation and function in early embryos. We show here that WRM-1 downregulates POP-1 by promoting its phosphorylation by the MAP kinase LIT-1 and subsequent nuclear export via a 14-3-3 protein, PAR-5. In signal-responsive cells, we also detect a concurrent upregulation of nuclear LIT-1 that is dependent on Wnt/MAPK signaling. Our results suggest a model whereby Wnt/MAPK signaling downregulates POP-1 levels in responsive cells, in part by increasing nuclear LIT-1 levels, thereby increasing POP-1 phosphorylation and PAR-5-mediated nuclear export."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(04)00203-x"xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(04)00203-x"xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Gay F."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Gay F."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Lo M.-C."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Lo M.-C."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Odom R."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/author | "Odom R."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/pages | "95-106"xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/pages | "95-106"xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/title | "Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/title | "Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/15066285 | http://purl.uniprot.org/core/volume | "117"xsd:string |