| http://purl.uniprot.org/citations/15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15067039 | http://www.w3.org/2000/01/rdf-schema#comment | "The rapid and robust immunoregulatory cytokine response of Va14Ja18 natural T (iNKT) cells to glycolipid Ags determines their diverse functions. Unlike conventional T cells, iNKT lymphocyte ontogeny absolutely requires NF-kappa B signaling. However, the precise role of NF-kappa B in iNKT cell function and the identity of upstream signals that activate NF-kappa B in this T cell subset remain unknown. Using mice in which iNKT cell ontogeny has been rescued despite inhibition of NF-kappa B signaling, we demonstrate that iNKT cell function requires NF-kappa B in a lymphocyte-intrinsic manner. Furthermore, the ontogeny of functional iNKT cells requires signaling through protein kinase C theta, which is dispensable for conventional T lymphocyte development. The unique requirement of protein kinase C theta implies that signals emanating from the TCR activate NF-kappa B during iNKT cell development and function. Thus, we conclude that NF-kappa B signaling plays a crucial role at distinct levels of iNKT cell biology."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.8.4667"xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/author | "Park J.J."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/author | "Bezbradica J.S."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/author | "Joyce S."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/author | "Boothby M.R."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/author | "Stanic A.K."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/pages | "4667-4671"xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/title | "Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B."xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/15067039 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15067039 |
| http://purl.uniprot.org/citations/15067039 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15067039 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J090-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_A6H667-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_B9VQY2-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_F8WGT6-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_E9Q395-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_F6Z9G5-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_Q02111-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |
| http://purl.uniprot.org/uniprot/#_P25799-mappedCitation-15067039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15067039 |