| http://purl.uniprot.org/citations/15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15070884 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundPrevious studies have demonstrated an association between recurrent miscarriage (RM) and the maternal HLA-DRB1*01 and -DRB1*03 alleles. The primary aim of the present study was to confirm or reject the hypothesis about this association in a larger case-control study.MethodsHLA-DRB1, -DQA1 and -DQB1 genotyping was carried out by the PCR-sequence-specific primer (SSP) method in 354 patients with unexplained RM and 202 fertile controls. These results were combined with the results from a previous study of 234 RM patients and 360 controls.ResultsThe prevalence of patients with HLA-DRB1*03 was significantly increased compared with controls [odds ratio (OR) = 1.4, 95% confidence interval (CI) = 1.1-1.9, P = 0.01, P corrected for the number of comparisons (Pc) = 0.02]. In patients with at least four previous miscarriages or with secondary RM, the association became even stronger (OR = 1.8, 95% CI = 1.3-2.5, P = 0.0005, Pc = 0.004; and OR = 1.8, 95% CI = 1.3-2.5, P = 0.0007, Pc = 0.006, respectively). There was no significant difference between patients and controls with regard to HLA-DRB1*01.ConclusionThe HLA-DRB1*03 allele or genes in linkage disequilibrium with it confer susceptibility to RM."xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.org/dc/terms/identifier | "doi:10.1093/humrep/deh200"xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/author | "Steffensen R."xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/author | "Kruse C."xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/author | "Christiansen O.B."xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/author | "Varming K."xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/name | "Hum Reprod"xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/pages | "1215-1221"xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/title | "A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage."xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/15070884 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15070884 |
| http://purl.uniprot.org/citations/15070884 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAC7-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE0-mappedCitation-15070884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15070884 |