Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/15072558http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15072558http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15072558http://www.w3.org/2000/01/rdf-schema#comment"The natriuretic peptide (NP) family is composed of three members: atrial, brain/ventricular and C-type NPs (ANP, BNP/VNP and CNP respectively) in tetrapods and teleostean fish, but only CNP in elasmobranch fish. In order to trace the process of divergence of the NP family in early vertebrate evolution, we attempted to detect NPs in the primitive ray-finned fish, the sturgeon (Acipenser transmontanus). Unexpectedly, we isolated four distinct NP cDNAs from the heart and brain of this chondrostean fish. The single NP from the brain was CNP, as judged from the lack of C-terminal 'tail' sequence extending from the intramolecular ring. Two of the three cardiac NPs were ANP and VNP, as judged by the presence of an amidation signal at its C-terminus (ANP) and a long and conserved C-terminal tail sequence (VNP) respectively. The third cardiac NP was most probably BNP because it possessed all the features characteristic of BNP including: (1) the presence of dibasic amino acids within the intramolecular ring; (2) the presence of AUUUA repeats in the 3'-untranslated region of its mRNA; (3) equivalent expression of its mRNA in the atrium and ventricle and appreciable expression in the brain. Based on the sturgeon BNP sequence, we further isolated BNP cDNA from the heart of tilapia and pufferfish for the first time in teleostean fish. Phylogenetic analysis of the precursors showed that newly identified NPs belong to each group of the four NPs. The current identification of both VNP and BNP in the sturgeon clearly showed that BNP and VNP are coded by distinct genes, and that the NP family consists of at least four members in the ray-finned fish. VNP has not been molecularly identified in mammals but its presence is suggested from physiological studies; heterologous fish VNP exhibited more potent vasorelaxant activity than homologous mammalian ANP in the isolated coronary artery of dogs."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.org/dc/terms/identifier"doi:10.1677/jme.0.0320547"xsd:string
http://purl.uniprot.org/citations/15072558http://purl.org/dc/terms/identifier"doi:10.1677/jme.0.0320547"xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Inoue K."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Inoue K."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Kobayashi Y."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Kobayashi Y."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Takei Y."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Takei Y."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Kawakoshi A."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Kawakoshi A."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Hyodo S."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/author"Hyodo S."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/name"J. Mol. Endocrinol."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/name"J. Mol. Endocrinol."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/pages"547-555"xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/pages"547-555"xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/title"Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/title"Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage."xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/volume"32"xsd:string
http://purl.uniprot.org/citations/15072558http://purl.uniprot.org/core/volume"32"xsd:string
▶