| http://purl.uniprot.org/citations/15072594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15072594 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic Y-box binding protein-1 (YB-1) functions in various biological processes, including transcriptional and translational control, DNA repair, drug resistance, and cell proliferation. To elucidate the physiological role of the YB-1 protein, we disrupted one allele of mouse YB-1 in embryonic stem (ES) cells. Northern blot analysis revealed that YB-1(+/-) ES cells with one intact allele contain approximately one-half the amount of mRNA detected in wild-type (YB-1(+/+)) cells. We further found that the protein level of YB-1(+/-) cells was reduced to approximately 50-60% compared with that of YB-1(+/+) cells. However, no apparent growth difference was found between YB-1(+/-) and YB-1(+/+) cells. YB-1(+/-) cells showed increased sensitivity to cisplatin and mitomycin C, but not to etoposide, X-ray or UV irradiation, as compared to YB-1(+/+) cells. YB-1 may have the capacity to exert a protective role against cytotoxic effects of DNA damaging agents, and may be involved in certain aspects of drug resistance."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2004.tb03214.x"xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Kohno K."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Nakabeppu Y."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Tominaga Y."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Kura S."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Tsuzuki T."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Uchiumi T."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Shibahara K."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Kuwano M."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/author | "Maehara Y."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/pages | "348-353"xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/title | "Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C."xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/15072594 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15072594 |
| http://purl.uniprot.org/citations/15072594 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15072594 |
| http://purl.uniprot.org/uniprot/#_A2BGG7-mappedCitation-15072594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15072594 |
| http://purl.uniprot.org/uniprot/#_Q71V06-mappedCitation-15072594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15072594 |
| http://purl.uniprot.org/uniprot/#_Q8BRJ5-mappedCitation-15072594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15072594 |
| http://purl.uniprot.org/uniprot/#_Q3UBT1-mappedCitation-15072594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15072594 |
| http://purl.uniprot.org/uniprot/#_P62960-mappedCitation-15072594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15072594 |