| http://purl.uniprot.org/citations/15073177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15073177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15073177 | http://www.w3.org/2000/01/rdf-schema#comment | "Deregulation of c-myc expression is implicated in the pathogenesis of many neoplasias. Estrogen receptor alpha (ERalpha) can increase the rate of c-myc transcription through the recruitment of a variety of cofactors to the promoter, yet the precise roles of these cofactors in transcription and tumorigenesis are largely unknown. We show here that a putative tumor suppressor TIP30, also called CC3 or Htatip2, interacts with an ERalpha-interacting coactivator CIA. Using chromatin immunoprecipitation assays, we demonstrate that TIP30 and CIA are distinct cofactors that are dynamically associated with the promoter and downstream regions of the c-myc gene in response to estrogen. Both TIP30 and CIA are recruited to the c-myc gene promoter by liganded ERalpha in the second transcription cycle. TIP30 overexpression represses ERalpha-mediated c-myc transcription, whereas TIP30 deficiency enhances c-myc transcription in both the absence and presence of estrogen. Ectopic CIA cooperates with TIP30 to repress ERalpha-mediated c-myc transcription. Moreover, virgin TIP30 knockout mice exhibit increased c-myc expression in mammary glands. Together, these results reveal an important role for TIP30 in the regulation of ERalpha-mediated c-myc transcription and suggest a mechanism for tumorigenesis promoted by TIP30 deficiency."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m401809200"xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m401809200"xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Bruck K."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Bruck K."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Piening V."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/author | "Piening V."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/pages | "27781-27789"xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/pages | "27781-27789"xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/title | "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription."xsd:string |
| http://purl.uniprot.org/citations/15073177 | http://purl.uniprot.org/core/title | "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription."xsd:string |