| http://purl.uniprot.org/citations/15073321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15073321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15073321 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in the caspase-9-activating apoptosome complex. Likewise, caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. We show that activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Because PIDD functions in p53-mediated apoptosis, the complex assembled by PIDD and caspase-2 is likely to regulate apoptosis induced by genotoxins."xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1095432"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1095432"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/author | "Tinel A."xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/author | "Tinel A."xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/pages | "843-846"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/pages | "843-846"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/title | "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress."xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/title | "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress."xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/volume | "304"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://purl.uniprot.org/core/volume | "304"xsd:string |
| http://purl.uniprot.org/citations/15073321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15073321 |
| http://purl.uniprot.org/citations/15073321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15073321 |
| http://purl.uniprot.org/citations/15073321 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15073321 |
| http://purl.uniprot.org/citations/15073321 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15073321 |
| http://purl.uniprot.org/uniprot/P42575 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15073321 |
| http://purl.uniprot.org/uniprot/P78560 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15073321 |