| http://purl.uniprot.org/citations/15077008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15077008 | http://www.w3.org/2000/01/rdf-schema#comment | "Dopamine is a key neurotransmitter of the mesolimbic reward pathway in the human brain, and tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Consequently, the gene encoding TH is a strong candidate for involvement in the genetic component of addiction. The importance of this gene in nicotine dependence is supported by many studies showing a link between nicotine administration and TH expression. A functional tetranucleotide repeat polymorphism within intron 1 of the TH gene (HUMTH01-VNTR) has been shown to modify tobacco use in two independent Caucasian samples from the USA and Australia. Using information drawn from an eight-wave Australian population-based longitudinal study of adolescent health, we tested the effect of the HUMTH01-VNTR on nicotine dependence. Comparisons were made between dependent smokers and non-dependent smokers. These data provide further support for a protective association between the K4 allele and dependent smoking (odds ratio 0.54, 95% confidence interval 0.28-1.0). No associations were observed at any of three other common TH polymorphisms (rs6356, rs6357 and HUMTH01-PstI). Including these data, three independent studies, two of which use identical phenotypes, have now identified a protective relationship between the K4 allele of the functional HUMTH01-VNTR polymorphism and high-level smoking."xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.org/dc/terms/identifier | "doi:10.1097/00008571-200402000-00001"xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/author | "Williamson R."xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/author | "Olsson C.A."xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/author | "Patton G.C."xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/author | "Anney R.J."xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/author | "Lotfi-Miri M."xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/name | "Pharmacogenetics"xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/pages | "73-81"xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/title | "Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism."xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15077008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15077008 |
| http://purl.uniprot.org/citations/15077008 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15077008 |
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