| http://purl.uniprot.org/citations/15077184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15077184 | http://www.w3.org/2000/01/rdf-schema#comment | "The EEN (extra eleven nineteen) gene was originally cloned from a case of acute myeloid leukemia M5 subtype with translocation t (11; 19)(q23; p13), in which EEN was fused with MLL. To explore the involvement of EEN in leukemogenesis caused by MLL-EEN, we studied the transformation potential of the MLL-EEN fusion protein. MLL-EEN had oncogenic features, while, as a control, MLLDelta, the truncated form of MLL lacking the EEN moiety, did not show any oncogenic potential. MLL-EEN exerted a dominant-negative effect over wild-type EEN in terms of subcellular localization. Normally, EEN was found in the cytoplasm, but the MLL-EEN fusion protein was located in the nucleus, and EEN could be delocalized by MLL-EEN. This interaction is via a coiled-coil dimerization domain of EEN, which is reserved in the fusion protein. In addition, MLL-EEN might act as a potential transcriptional factor with the MLL part providing the DNA-binding domain and the EEN part providing the transcription activation domain, though EEN seems to have no direct role in transcriptional regulation. As an aberrant transcriptional factor, MLL-EEN could transactivate the promoter of HoxA7, a potential target gene of MLL."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207402"xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Wang Z.G."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Li B.L."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Chen S.J."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Zhang Q.H."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/author | "Huang Q.H."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/pages | "3385-3394"xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/title | "Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein."xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15077184 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15077184 |
| http://purl.uniprot.org/citations/15077184 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15077184 |
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| http://purl.uniprot.org/uniprot/#_Q6FGM0-mappedCitation-15077184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15077184 |
| http://purl.uniprot.org/uniprot/#_Q9BVL7-mappedCitation-15077184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15077184 |
| http://purl.uniprot.org/uniprot/#_Q9BWP4-mappedCitation-15077184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15077184 |
| http://purl.uniprot.org/uniprot/#_Q9UQD4-mappedCitation-15077184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15077184 |
| http://purl.uniprot.org/uniprot/Q6FGM0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15077184 |